"I was born twice: first, as a baby girl, on a remarkably smogless Detroit day in January of 1960; and then again, as a teenage boy, in an emergency room near Petoskey, Michigan, in August of 1974." And so begins Middlesex, the mesmerizing saga of a near-mythic Greek American family and the "roller-coaster ride of a single gene through time." The odd but utterly believable story of Cal Stephanides, and how this 41-year-old hermaphrodite was raised as Calliope, is at the tender heart of this long-awaited second novel from Jeffrey Eugenides.

Eugenides weaves together a kaleidoscopic narrative spanning 80 years of a stained family history, from a fateful incestuous union in a small town in early 1920s Asia Minor to Prohibition-era Detroit; from the early days of Ford Motors to the heated 1967 race riots; from the tiny suburbs of Grosse Pointe and a confusing, aching adolescent love story to modern-day Berlin. Eugenides's command of the narrative is astonishing. He balances Cal/Callie's shifting voices convincingly, spinning this strange and often unsettling story with intelligence, insight, and generous amounts of humor. If you get a chance, read Middlesex - I hope you find it as touching and at times as hilarious as I did.